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SUNDAY, Dec. 8, 2013 (HealthDay News) Preliminary research shows that gene therapy might one day be a powerful weapon against leukemia and other blood cancers.
Gene Therapy Shows Promise Against Leukemia
In the studies, researchers filtered the patients' blood, removing white blood cells known as T cells that are part of the body's immune system. They then added a gene to the T cells that would target cancer White Adidas Sweatshirt cells. The altered T cells were returned to the patients' body in infusions that were given over the course of three days.
alternative for those with blood cancers.
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At this point, more than 120 patients with different types of blood and bone marrow cancers have been given the treatment, according to the wire service, and many have gone into remission and stayed in remission up to three years later.
All the patients in the studies had few options left, the researchers noted in the news release. Many were ineligible for bone marrow transplantation or did not want that treatment because of the dangers associated with the procedure, which carries at least a 20 percent mortality risk.
In one study, all five adults and 19 of 22 children with acute lymphocytic leukemia (ALL) were cleared of the cancer. A few have relapsed since the study was Red Adidas Long Sleeve
Several companies are developing these types of cancer therapies, and a clinical trial next year could lead to federal approval of the treatment by 2016, the AP reported.
"Our findings show that the human immune system and these modified 'hunter' cells are working together to attack tumors in an entirely new way," research leader Dr. Carl June, professor in immunotherapy in the department of pathology and laboratory medicine and director of translational research at Penn's Abramson Cancer Center, said in the news release.
"It's really exciting," Dr. Janis Abkowitz, blood diseases chief at the University of Washington in Seattle and president of the American Society of Hematology, told the Associated Press. "You can take a cell that belongs to a patient and engineer it to be an attack cell."
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In another trial, 15 of 32 patients with chronic lymphocytic leukemia (CLL) initially responded to the therapy and seven have experienced a complete remission of their disease, according to a news release from the trial researchers, who are from the University of Pennsylvania.
major advance," Lee Greenberger, chief scientific officer of the Leukemia and Lymphoma Society, told the AP. "We are seeing powerful responses. and time will tell how enduring these remissions turn out to be."
The experimental treatment coaxed certain blood cells into targeting and destroying cancer cells, according to research presented this weekend at the American Society of Hematology's annual meeting in New Orleans.
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